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It binds G-actin monomers with high affinity, sequestering monomeric actin and controlling its availability for polymerization

Subsequently, glutamate provides a substrate for the synthesis of -ketoglutarate, the key metabolite of the TCA cycle (9)

In specific embodiments, osmolarity/osmolality of the present formulations or compositions is adjusted, for example, by the use of appropriate salt concentrations (e.g., concentration of sodium salts) or the use of tonicity agents which renders the formulations or compositions endolymph-compatible and/or perilymph compatible (i.e

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Die richtige Berechnung von Konzentration und Injektionsvolumen wirkt trivial, ist aber die hufigste Fehlerquelle

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